Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1TVH

Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2

Summary for 1TVH
Entry DOI10.2210/pdb1tvh/pdb
Related1DUZ 1QR1 1TVB
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, epitope of Melanocyte protein Pmel 17, ... (5 entities in total)
Functional Keywordsmelanoma; x-ray; modified gp100 peptide; gp100(209-t2m) peptide; mhc; hla-a2, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967
Total number of polymer chains6
Total formula weight92116.18
Authors
Borbulevych, O.Y.,Baker, B.M. (deposition date: 2004-06-29, release date: 2005-04-19, Last modification date: 2023-08-23)
Primary citationBorbulevych, O.Y.,Baxter, T.K.,Yu, Z.,Restifo, N.P.,Baker, B.M.
Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design
J.Immunol., 174:4812-4820, 2005
Cited by
PubMed: 15814707
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.802 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon