1TVB

Crystal structure of Melanoma Antigen gp100(209-217) Bound to Human Class I MHC HLA-A2

Summary for 1TVB

Entry DOI	10.2210/pdb1tvb/pdb
Related	1DUZ 1QR1 1TVH
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, epitope of Melanocyte protein Pmel 17, ... (5 entities in total)
Functional Keywords	melanoma; x-ray; gp100; peptide; mhc; hla-a2, immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967
Total number of polymer chains	6
Total formula weight	91503.43
Authors	Borbulevych, O.Y.,Baker, B.M. (deposition date: 2004-06-29, release date: 2005-04-19, Last modification date: 2011-07-13)
Primary citation	Borbulevych, O.Y.,Baxter, T.K.,Yu, Z.,Restifo, N.P.,Baker, B.M. Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design J.Immunol., 174:4812-4820, 2005 Cited by PubMed: 15814707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation