1TSR

P53 CORE DOMAIN IN COMPLEX WITH DNA

Summary for 1TSR

• Entry DOI: 10.2210/pdb1tsr/pdb
• Descriptor: DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR), ... (5 entities in total)
• Functional Keywords: tumor suppressor, anti-oncogene, antitumor protein-dna complex, antitumor protein/dna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 5
• Total formula weight: 86840.24

Authors

Cho, Y.,Gorina, S.,Jeffrey, P.,Pavletich, N. (deposition date: 1995-07-28, release date: 1996-01-29, Last modification date: 2024-02-14)

• Primary citation: Cho, Y.,Gorina, S.,Jeffrey, P.D.,Pavletich, N.P.; Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.; Science, 265:346-355, 1994; PubMed: 8023157

Experimental method

X-RAY DIFFRACTION (2.2 Å)