1TSQ

CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT

1TSQ の概要

• エントリーDOI: 10.2210/pdb1tsq/pdb
• 分子名称: Pol polyprotein, AP2V NC-P1 SUBSTRATE PEPTIDE, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: co-evolution, nucleocapdis, substrate recognition, hiv-1 protease, hydrolase-viral protein complex, hydrolase/viral protein
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 23326.28

構造登録者

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2004-06-21, 公開日: 2005-03-29, 最終更新日: 2023-08-23)

• 主引用文献: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease; J.Virol., 78:12446-12454, 2004; PubMed: 15507631; DOI: 10.1128/JVI.78.22.12446-12454.2004

実験手法

X-RAY DIFFRACTION (2 Å)