1T9N

Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

1T9N の概要

• エントリーDOI: 10.2210/pdb1t9n/pdb
• 分子名称: Carbonic anhydrase II, ZINC ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: proton shuttle, carbonic anhydrase, metalloenzyme, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29450.53

構造登録者

Fisher, Z.,Hernandez Prada, J.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. (登録日: 2004-05-18, 公開日: 2005-01-25, 最終更新日: 2023-08-23)

• 主引用文献: Fisher, Z.,Hernandez Prada, J.A.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R.; Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II; Biochemistry, 44:1097-1105, 2005; PubMed: 15667203; DOI: 10.1021/bi0480279

実験手法

X-RAY DIFFRACTION (2 Å)