1SVH

Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8

1SVH の概要

• エントリーDOI: 10.2210/pdb1svh/pdb
• 関連するPDBエントリー: 1SVE 1SVG 1VEB
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, (3R,4S)-N-(4-{TRANS-2-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-PHENYL]-VINYL}-AZEPAN-3-YL)-ISONICOTINAMIDE, ... (4 entities in total)
• 機能のキーワード: kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43422.37

構造登録者

Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B. (登録日: 2004-03-29, 公開日: 2005-03-29, 最終更新日: 2011-07-13)

• 主引用文献: Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B.; Structure-based optimization of novel azepane derivatives as PKB inhibitors; J.Med.Chem., 47:1375-1390, 2004; PubMed: 14998327; DOI: 10.1021/jm0310479

実験手法

X-RAY DIFFRACTION (2.3 Å)