1SJ0

Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D

Summary for 1SJ0

Entry DOI	10.2210/pdb1sj0/pdb
Descriptor	Estrogen receptor, (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL (3 entities in total)
Functional Keywords	nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	1
Total formula weight	28779.91
Authors	Kim, S.,Wu, J.Y.,Birzin, E.T.,Chan, W.,Pai, L.Y.,Yang, Y.T.,Mosley, R.T.,Fitzgerald, P.M.,Sharma, N.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. (deposition date: 2004-03-02, release date: 2004-04-27, Last modification date: 2024-02-14)
Primary citation	Kim, S.,Wu, J.Y.,Birzin, E.T.,Frisch, K.,Chan, W.,Pai, L.Y.,Yang, Y.T.,Mosley, R.T.,Fitzgerald, P.M.,Sharma, N.,Dahllund, J.,Thorsell, A.G.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators. J.Med.Chem., 47:2171-2175, 2004 Cited by PubMed: 15084115 DOI: 10.1021/jm034243o PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation