1RRI

DHNA complex with 3-(5-amino-7-hydroxy-[1,2,3] triazolo [4,5-d]pyrimidin-2-yl)-benzoic acid

Summary for 1RRI

Entry DOI	10.2210/pdb1rri/pdb
Related	1RR5 1RRW 1RRY 1RS2 1RS4 1RSD 1RSI
Descriptor	Dihydroneopterin aldolase, 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-BENZOIC ACID (2 entities in total)
Functional Keywords	dhna complex with 3-(5-amino-7-hydroxy-[1, 2, 3] triazolo [4, 5-d]pyrimidin-2-yl)-benzoic acid, lyase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	14041.85
Authors	Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A. (deposition date: 2003-12-08, release date: 2004-03-30, Last modification date: 2024-02-14)
Primary citation	Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A. Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47:1709-1718, 2004 Cited by PubMed: 15027862 DOI: 10.1021/jm030497y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation