1RHK

Crystal structure of the complex of caspase-3 with a phenyl-propyl-ketone inhibitor

Summary for 1RHK

• Entry DOI: 10.2210/pdb1rhk/pdb
• Related: 1PAU 1RHJ 1RHM 1RHQ 1RHR 1RHU
• Related PRD ID: PRD_000231
• Descriptor: Caspase-3, acetyl-asp-glu-val-fpr, ... (4 entities in total)
• Functional Keywords: cysteine protease, caspase-3, apopain, cpp32, yama, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 3
• Total formula weight: 29155.15

Authors

Becker, J.W.,Rotonda, J.,Soisson, S.M. (deposition date: 2003-11-14, release date: 2004-05-11, Last modification date: 2023-09-20)

• Primary citation: Becker, J.W.,Rotonda, J.,Soisson, S.M.,Aspiotis, R.,Bayly, C.,Francoeur, S.,Gallant, M.,Garcia-Calvo, M.,Giroux, A.,Grimm, E.,Han, Y.,McKay, D.,Nicholson, D.W.,Peterson, E.,Renaud, J.,Roy, S.,Thornberry, N.,Zamboni, R.; Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis.; J.Med.Chem., 47:2466-2474, 2004; PubMed: 15115390; DOI: 10.1021/jm0305523

Experimental method

X-RAY DIFFRACTION (2.5 Å)