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1R78

CDK2 complex with a 4-alkynyl oxindole inhibitor

Summary for 1R78
Entry DOI10.2210/pdb1r78/pdb
Related1fvt 1p2a
DescriptorCell division protein kinase 2, 4-((3R,4S,5R)-4-AMINO-3,5-DIHYDROXY-HEX-1-YNYL)-5-FLUORO-3-[1-(3-METHOXY-1H-PYRROL-2-YL)-METH-(Z)-YLIDENE]-1,3-DIHYDRO-INDOL-2-ONE (3 entities in total)
Functional Keywordscyclin dependent kinase, serine/threonine protein kinase, oxindole, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight34361.88
Authors
Luk, K.-C.,Simcox, M.E.,Schutt, A.,Rowan, K.,Thompson, T.,Chen, Y.,Kammlott, U.,DePinto, W.,Dunten, P.,Dermatakis, A. (deposition date: 2003-10-20, release date: 2004-01-20, Last modification date: 2024-02-14)
Primary citationLuk, K.-C.,Simcox, M.E.,Schutt, A.,Rowan, K.,Thompson, T.,Chen, Y.,Kammlott, U.,DePinto, W.,Dunten, P.,Dermatakis, A.
A new series of potent oxindole inhibitors of CDK2
Bioorg.Med.Chem.Lett., 14:913-917, 2004
Cited by
PubMed: 15012993
DOI: 10.1016/j.bmcl.2003.12.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

数据于2024-03-27公开中

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