1R5K

Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638

Summary for 1R5K

Entry DOI	10.2210/pdb1r5k/pdb
Descriptor	Estrogen receptor, (2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID (3 entities in total)
Functional Keywords	alpha helix, helical sandwich, dna binding protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains	3
Total formula weight	90613.97
Authors	Wu, Y.-L.,Yang, X.,Ren, Z.,McDonnell, D.P.,Norris, J.D.,Willson, T.M.,Greene, G.L. (deposition date: 2003-10-10, release date: 2004-11-23, Last modification date: 2023-08-23)
Primary citation	Wu, Y.L.,Yang, X.,Ren, Z.,McDonnell, D.P.,Norris, J.D.,Willson, T.M.,Greene, G.L. Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol.Cell, 18:413-424, 2005 Cited by PubMed: 15893725 DOI: 10.1016/j.molcel.2005.04.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation