1QR1

POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE

Summary for 1QR1

• Entry DOI: 10.2210/pdb1qr1/pdb
• Related: 1hhg 1hhh 1hhi 1hhj 1hhk
• Descriptor: HLA-A2.1 HEAVY CHAIN, BETA-2 MICROGLOBULIN, GP2 PEPTIDE, ... (4 entities in total)
• Functional Keywords: peptide-binding superdomain, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• Total number of polymer chains: 6
• Total formula weight: 89235.35

Authors

Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J. (deposition date: 1999-06-17, release date: 2000-01-01, Last modification date: 2021-11-03)

• Primary citation: Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J.; Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.; J.Biol.Chem., 274:36422-36427, 1999; PubMed: 10593938; DOI: 10.1074/jbc.274.51.36422

Experimental method

X-RAY DIFFRACTION (2.4 Å)