1Q8T

The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632

1Q8T の概要

• エントリーDOI: 10.2210/pdb1q8t/pdb
• 関連するPDBエントリー: 1Q8U 1Q8W
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: kinase-inhibitor-complex, phosphotransferase/inhibitor, camp, phosphorylation, serine/threonine-protein kinase, atp-binding, pka, rho-kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43260.14

構造登録者

Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D. (登録日: 2003-08-22, 公開日: 2003-12-16, 最終更新日: 2011-07-13)

• 主引用文献: Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D.; Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.; Structure, 11:1595-1607, 2003; PubMed: 14656443; DOI: 10.1016/j.str.2003.11.002

実験手法

X-RAY DIFFRACTION (2 Å)