1PXP

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine

1PXP の概要

• エントリーDOI: 10.2210/pdb1pxp/pdb
• 関連するPDBエントリー: 1AQ1 1B39 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1FIN 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GZ8 1HCK 1HCL 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1PXM 1PXN 1PXO
• 分子名称: Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding, 3d-structure.
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34301.92

構造登録者

Wang, S.,Meades, C.,Wood, G.,Osnowski, A.,Anderson, S.,Yuill, R.,Thomas, M.,Mezna, M.,Jackson, W.,Midgley, C.,Griffiths, G.,McNae, I.,Wu, S.Y.,McInnes, C.,Zheleva, D.,Walkinshaw, M.D.,Fischer, P.M. (登録日: 2003-07-04, 公開日: 2004-04-13, 最終更新日: 2023-08-16)

• 主引用文献: Wang, S.,Meades, C.,Wood, G.,Osnowski, A.,Anderson, S.,Yuill, R.,Thomas, M.,Mezna, M.,Jackson, W.,Midgley, C.,Griffiths, G.,Fleming, I.,Green, S.,McNae, I.,Wu, S.Y.,McInnes, C.,Zheleva, D.,Walkinshaw, M.D.,Fischer, P.M.; 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.; J.Med.Chem., 47:1662-1675, 2004; PubMed: 15027857; DOI: 10.1021/jm0309957

実験手法

X-RAY DIFFRACTION (2.3 Å)