1PJ3

Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate.

Summary for 1PJ3

• Entry DOI: 10.2210/pdb1pj3/pdb
• Related: 1PJ2 1PJ4
• Descriptor: NAD-dependent malic enzyme, mitochondrial, MANGANESE (II) ION, PYRUVIC ACID, ... (6 entities in total)
• Functional Keywords: oxidative decarboxylase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion matrix: P23368
• Total number of polymer chains: 4
• Total formula weight: 261916.36

Authors

Tao, X.,Yang, Z.,Tong, L. (deposition date: 2003-05-30, release date: 2003-11-11, Last modification date: 2023-11-15)

• Primary citation: Tao, X.,Yang, Z.,Tong, L.; Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.; Structure, 11:1141-1150, 2003; PubMed: 12962632; DOI: 10.1016/S0969-2126(03)00168-0

Experimental method

X-RAY DIFFRACTION (2.1 Å)