1ONZ

Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b

Summary for 1ONZ

• Entry DOI: 10.2210/pdb1onz/pdb
• Related: 1NL9 1NNY 1NZ7 1No6 1ONY
• Descriptor: Protein-tyrosine phosphatase, non-receptor type 1, 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID (3 entities in total)
• Functional Keywords: protein tyrosine phosphatase, oxalyl-aryl-benzoic acid compound with napthyl moiety anchor inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 1
• Total formula weight: 37716.95

Authors

Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R. (deposition date: 2003-03-02, release date: 2003-05-20, Last modification date: 2023-08-16)

• Primary citation: Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R.; Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B; J.Med.Chem., 46:2093-2103, 2003; PubMed: 12747781; DOI: 10.1021/jm0205696

Experimental method

X-RAY DIFFRACTION (2.4 Å)