1ONY

Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17

1ONY の概要

• エントリーDOI: 10.2210/pdb1ony/pdb
• 関連するPDBエントリー: 1NL9 1NNY 1NZ7 1No6 1onz
• 分子名称: Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, oxalyl-aryl-amino benzoic acid inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37954.27

構造登録者

Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R. (登録日: 2003-03-02, 公開日: 2003-05-20, 最終更新日: 2023-08-16)

• 主引用文献: Liu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R.; Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B; J.Med.Chem., 46:2093-2103, 2003; PubMed: 12747781; DOI: 10.1021/jm0205696

実験手法

X-RAY DIFFRACTION (2.15 Å)