1OKZ

Structure of human PDK1 kinase domain in complex with UCN-01

Summary for 1OKZ

Entry DOI	10.2210/pdb1okz/pdb
Related	1H1W 1OKY 1UU3 1UU7 1UU8 1UU9 1UVR
Descriptor	3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywords	protein kinase, pkb, pdk1, ucn-01, 7-hydroxy staurosporine, inhibitor, transferase, atp-binding, phosphorylation
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37014.10
Authors	Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-08-01, release date: 2004-07-29, Last modification date: 2023-12-13)
Primary citation	Komander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F. Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition Biochem.J., 375:255-, 2003 Cited by PubMed: 12892559 DOI: 10.1042/BJ20031119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation