1NRL

Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813

1NRL の概要

• エントリーDOI: 10.2210/pdb1nrl/pdb
• 関連するPDBエントリー: 1ILG 1ILH 1M13
• 分子名称: Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, coactivator, pxr, xenobiotic, src-1, ligand binding domain, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: O75469
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 79183.13

構造登録者

Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R. (登録日: 2003-01-25, 公開日: 2003-08-19, 最終更新日: 2024-02-14)

• 主引用文献: Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R.; Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor; J.Mol.Biol., 331:815-828, 2003; PubMed: 12909012; DOI: 10.1016/S0022-2836(03)00795-2

実験手法

X-RAY DIFFRACTION (2 Å)