1N95

Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives

Summary for 1N95

Entry DOI	10.2210/pdb1n95/pdb
Related	1N94 1N9A
Descriptor	Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
Functional Keywords	farnesyltransferase, histidine tetrahydropyridine, prenyltransferase, transferase
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	2
Total formula weight	83867.52
Authors	Gwaltney II, S.L.,O'Conner, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z. (deposition date: 2002-11-22, release date: 2003-01-07, Last modification date: 2024-02-14)
Primary citation	Gwaltney II, S.L.,O'Connor, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z.,Tahir, S.K.,Bauch, J.,Marsh, K.,Ng, S.C.,Frost, D.J.,Zhang, H.,Muchmore, S.,Jakob, C.G.,Stoll, V.,Hutchins, C.,Rosenberg, S.H.,Sham, H.L. Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorg.Med.Chem.Lett., 13:1359-1362, 2003 Cited by PubMed: 12657282 DOI: 10.1016/S0960-894X(03)00095-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation