1N2R

A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.

Summary for 1N2R

• Entry DOI: 10.2210/pdb1n2r/pdb
• Related: 1M6O
• Descriptor: HLA class I histocompatibility antigen, BW-44(B-12) B*4403 alpha chain, Beta-2-microglobulin, HLA DPA*0201 PEPTIDE, ... (5 entities in total)
• Functional Keywords: mhc i, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P30481; Secreted: P61769
• Total number of polymer chains: 3
• Total formula weight: 44936.76

Authors

Macdonald, W.A.,Purcell, A.W.,Williams, D.S.,Mifsud, N.,Ely, L.K.,Gorman, J.J.,Clements, C.S.,Kjer-Nielsen, L.,Koelle, D.M.,Brooks, A.G.,Lovrecz, G.O.,Lu, L.,Rossjohn, J.,McCluskey, J. (deposition date: 2002-10-24, release date: 2004-03-16, Last modification date: 2011-07-13)

• Primary citation: Macdonald, W.A.,Purcell, A.W.,Mifsud, N.A.,Ely, L.K.,Williams, D.S.,Chang, L.,Gorman, J.J.,Clements, C.S.,Kjer-Nielsen, L.,Koelle, D.M.,Burrows, S.R.,Tait, B.D.,Holdsworth, R.,Brooks, A.G.,Lovrecz, G.O.,Lu, L.,Rossjohn, J.,McCluskey, J.; A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.; J.Exp.Med., 198:679-691, 2003; PubMed: 12939341; DOI: 10.1084/jem.20030066

Experimental method

X-RAY DIFFRACTION (1.7 Å)