1MTR

HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR

1MTR の概要

• エントリーDOI: 10.2210/pdb1mtr/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000269
• 分子名称: HIV-1 PROTEASE, SULFATE ION, [1-BENZYL-3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YLAMINO)-2-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER, ... (4 entities in total)
• 機能のキーワード: aspartyl proteinase, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22416.32

構造登録者

Wickramasinghe, W.,Begun, J.,Martin, J.L. (登録日: 1996-02-15, 公開日: 1996-08-01, 最終更新日: 2023-08-09)

• 主引用文献: March, D.R.,Abbenante, G.,Bergman, D.A.,Brinkworth, R.I.,Wickramasinghe, W.,Begun, J.,Martin, J.L.,Fairlie, D.P.; Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode.; J.Am.Chem.Soc., 118:3375-3379, 1996

実験手法

X-RAY DIFFRACTION (1.75 Å)