1LK3

ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT

Summary for 1LK3

• Entry DOI: 10.2210/pdb1lk3/pdb
• Related: 1J7V
• Descriptor: Interleukin-10, 9D7 Light Chain, 9D7 Heavy Chain, ... (4 entities in total)
• Functional Keywords: antigen-antibody complex, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P22301
• Total number of polymer chains: 6
• Total formula weight: 129688.41

Authors

Josephson, K.,Jones, B.C.,Walter, L.J.,DiGiacomo, R.,Indelicato, S.R.,Walter, M.R. (deposition date: 2002-04-23, release date: 2002-07-17, Last modification date: 2011-07-13)

• Primary citation: Josephson, K.,Jones, B.C.,Walter, L.J.,DiGiacomo, R.,Indelicato, S.R.,Walter, M.R.; Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.; Structure, 10:981-987, 2002; PubMed: 12121653; DOI: 10.1016/S0969-2126(02)00791-8

Experimental method

X-RAY DIFFRACTION (1.91 Å)