1JSV

The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

Summary for 1JSV

• Entry DOI: 10.2210/pdb1jsv/pdb
• Descriptor: CELL DIVISION PROTEIN KINASE 2, 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE (3 entities in total)
• Functional Keywords: cdk2, serine/threonine protein kinase, cell cycle, atp-binding, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• Total number of polymer chains: 1
• Total formula weight: 34241.78

Authors

Watenpaugh, K.D.,Kelley, L.C. (deposition date: 2001-08-19, release date: 2001-08-29, Last modification date: 2024-02-07)

• Primary citation: Clare, P.M.,Poorman, R.A.,Kelley, L.C.,Watenpaugh, K.D.,Bannow, C.A.,Leach, K.L.; The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism; J.Biol.Chem., 276:48292-48299, 2001; PubMed: 11604388

Experimental method

X-RAY DIFFRACTION (1.96 Å)