1IDT

STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE

1IDT の概要

• エントリーDOI: 10.2210/pdb1idt/pdb
• 分子名称: MINOR FMN-DEPENDENT NITROREDUCTASE, FLAVIN MONONUCLEOTIDE, 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, ... (4 entities in total)
• 機能のキーワード: fmn, bioreductive activation, prodrug, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49291.42

構造登録者

Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (登録日: 2001-04-05, 公開日: 2003-09-16, 最終更新日: 2023-08-09)

• 主引用文献: Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S.; Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.; J.Med.Chem., 46:4009-4020, 2003; PubMed: 12954054; DOI: 10.1021/jm030843b

実験手法

X-RAY DIFFRACTION (2 Å)