1HV7

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

Summary for 1HV7

Entry DOI	10.2210/pdb1hv7/pdb
Descriptor	ELASTASE 1, SULFATE ION, N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE, ... (4 entities in total)
Functional Keywords	serine protease-inhibitor complex, hydrolase
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26424.63
Authors	Skarzynski, T.,Singh, O.M. (deposition date: 2001-01-08, release date: 2001-01-17, Last modification date: 2011-07-13)
Primary citation	Macdonald, S.J.,Dowle, M.D.,Harrison, L.A.,Shah, P.,Johnson, M.R.,Inglis, G.G.,Clarke, G.D.,Smith, R.A.,Humphreys, D.,Molloy, C.R.,Amour, A.,Dixon, M.,Murkitt, G.,Godward, R.E.,Padfield, T.,Skarzynski, T.,Singh, O.M.,Kumar, K.A.,Fleetwood, G.,Hodgson, S.T.,Hardy, G.W.,Finch, H. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate Bioorg.Med.Chem.Lett., 11:895-898, 2001 Cited by PubMed: 11294386 DOI: 10.1016/S0960-894X(01)00078-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation