1H2M

Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide

Summary for 1H2M

• Entry DOI: 10.2210/pdb1h2m/pdb
• Related: 1D7G 1H2K 1H2L 1H2N 1L8C 1LM8 1LQB
• Descriptor: FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ... (6 entities in total)
• Functional Keywords: transcription activator-inhibitor complex, fih, hif, dsbh, oxygenase, transcription, hypoxia, 2- oxoglutarate, asparaginyl hydroxylase, hydroxylase, transcription activator/inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm : Q16665
• Total number of polymer chains: 2
• Total formula weight: 46395.19

Authors

Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Schlemminger, I.,Seibel, J.F.,Schofield, C.J. (deposition date: 2002-08-12, release date: 2002-11-28, Last modification date: 2018-02-21)

• Primary citation: Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Seibel, J.F.,Schlemminger, I.,Pugh, C.,Ratcliffe, P.,Schofield, C.J.; Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha; J.Biol.Chem., 278:1802-1806, 2003; PubMed: 12446723; DOI: 10.1074/JBC.C200644200

Experimental method

X-RAY DIFFRACTION (2.5 Å)