1H26

CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53

Summary for 1H26

• Entry DOI: 10.2210/pdb1h26/pdb
• Related: 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1QMZ 1TSR 1TUP 1YCQ 1YCS 3SAK
• Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELLULAR TUMOR ANTIGEN P53, ... (4 entities in total)
• Functional Keywords: cell cycle, protein kinase, cyclin, cdk2, recruitment, peptide specificity
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus: P20248; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 5
• Total formula weight: 129810.35

Authors

Tews, I.,Cheng, K.Y.,Lowe, E.D.,Noble, M.E.M.,Brown, N.R.,Gul, S.,Gamblin, S.,Johnson, L.N. (deposition date: 2002-07-31, release date: 2003-02-01, Last modification date: 2023-12-13)

• Primary citation: Lowe, E.D.,Tews, I.,Cheng, K.Y.,Brown, N.R.,Gul, S.,Noble, M.E.M.,Gamblin, S.,Johnson, L.N.; Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A; Biochemistry, 41:15625-, 2002; PubMed: 12501191; DOI: 10.1021/BI0268910

Experimental method

X-RAY DIFFRACTION (2.24 Å)