1H07

CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor

1H07 の概要

• エントリーDOI: 10.2210/pdb1h07/pdb
• 関連するPDBエントリー: 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H08 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1QMZ
• 分子名称: CELL DIVISION PROTEIN KINASE 2, ((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE, ((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2S)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, mitosis, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35025.35

構造登録者

Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.,Green, S.,Jewsbury, P.J.,Midgley, C.J.,Naven, R.T.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E. (登録日: 2002-06-11, 公開日: 2003-07-11, 最終更新日: 2011-07-13)

• 主引用文献: Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.,Green, S.,Jewsbury, P.J.,Midgley, C.J.,Naven, R.T.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E.; Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines; Bioorg.Med.Chem.Lett., 13:2955-, 2003; PubMed: 12941311; DOI: 10.1016/S0960-894X(03)00202-6

実験手法

X-RAY DIFFRACTION (1.85 Å)