1GZ8

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-Amino-6-(3'-methyl-2'-oxo)butoxypurine

Summary for 1GZ8

• Entry DOI: 10.2210/pdb1gz8/pdb
• Related: 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1QMZ
• Descriptor: CELL DIVISION PROTEIN KINASE 2, 1-[(2-AMINO-6,9-DIHYDRO-1H-PURIN-6-YL)OXY]-3-METHYL-2-BUTANOL (3 entities in total)
• Functional Keywords: kinase, protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding, 3d-structure.
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 34269.77

Authors

Davies, T.,Endicott, J.,Johnson, L.,Noble, M.,Tucker, J. (deposition date: 2002-05-17, release date: 2003-06-12, Last modification date: 2023-12-13)

• Primary citation: Gibson, A.E.,Arris, C.E.,Bentley, J.,Boyle, F.T.,Curtin, N.J.,Davies, T.G.,Endicott, J.A.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Mesguiche, V.,Newell, D.R.,Noble, M.E.,Tucker, J.A.,Whitfield, H.J.; Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives; J.Med.Chem., 45:3381-, 2002; PubMed: 12139449; DOI: 10.1021/JM020056Z

Experimental method

X-RAY DIFFRACTION (1.3 Å)