1G5S

CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717

Summary for 1G5S

Entry DOI	10.2210/pdb1g5s/pdb
Descriptor	CELL DIVISION PROTEIN KINASE 2, 2-[TRANS-(4-AMINOCYCLOHEXYL)AMINO]-6-(BENZYL-AMINO)-9-CYCLOPENTYLPURINE (3 entities in total)
Functional Keywords	protein-inhibitor complex, cell cycle-transferase complex, cell cycle/transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34382.03
Authors	Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.-H. (deposition date: 2000-11-02, release date: 2001-11-02, Last modification date: 2023-08-09)
Primary citation	Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.H. Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717. J.Med.Chem., 44:524-530, 2001 Cited by PubMed: 11170642 DOI: 10.1021/jm001043t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation