1FV0

FIRST STRUCTURAL EVIDENCE OF THE INHIBITION OF PHOSPHOLIPASE A2 BY ARISTOLOCHIC ACID: CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN PHOSPHOLIPASE A2 AND ARISTOLOCHIC ACID

Summary for 1FV0

Entry DOI	10.2210/pdb1fv0/pdb
Related	1CL5 1FE7
Descriptor	PHOSPHOLIPASE A2, SULFATE ION, ACETATE ION, ... (7 entities in total)
Functional Keywords	phospholipase a2, daboia russelli pulchella, neurotoxic, edema, toxin
Biological source	Daboia russellii pulchella
Cellular location	Secreted : P59071
Total number of polymer chains	2
Total formula weight	28420.50
Authors	Chandra, V.,Jasti, J.,Kaur, P.,Srinivasan, A.,Betzel, C.,Singh, T.P. (deposition date: 2000-09-18, release date: 2002-08-28, Last modification date: 2023-08-09)
Primary citation	Chandra, V.,Jasti, J.,Kaur, P.,Srinivasan, A.,Betzel, C.,Singh, T.P. Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 A Crystal Structure Biochemistry, 41:10914-10919, 2002 Cited by PubMed: 12206661 DOI: 10.1021/bi0258593 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation