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1EAT

NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES

Summary for 1EAT
Entry DOI10.2210/pdb1eat/pdb
DescriptorPORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywordshydrolase (serine protease)
Biological sourceSus scrofa (pig)
Cellular locationSecreted: P00772
Total number of polymer chains1
Total formula weight26632.62
Authors
Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2012-02-22)
Primary citationVeale, C.A.,Bernstein, P.R.,Bryant, C.,Ceccarelli, C.,Damewood Jr., J.R.,Earley, R.,Feeney, S.W.,Gomes, B.,Kosmider, B.J.,Steelman, G.B.,Thomas, R.M.,Vacek, E.P.,Williams, J.C.,Wolanin, D.J.,Woolson, S.
Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
J.Med.Chem., 38:98-108, 1995
Cited by
PubMed: 7837246
DOI: 10.1021/jm00001a015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

數據於2024-03-27公開中

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