1EAS
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
Summary for 1EAS
Entry DOI | 10.2210/pdb1eas/pdb |
Descriptor | PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase (serine protease) |
Biological source | Sus scrofa (pig) |
Cellular location | Secreted: P00772 |
Total number of polymer chains | 1 |
Total formula weight | 26727.69 |
Authors | Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2012-02-22) |
Primary citation | Bernstein, P.R.,Andisik, D.,Bradley, P.K.,Bryant, C.B.,Ceccarelli, C.,Damewood Jr., J.R.,Earley, R.,Edwards, P.D.,Feeney, S.,Gomes, B.C.,Kosmider, B.J.,Steelman, G.B.,Thomas, R.M.,Vacek, E.P.,Veale, C.A.,Williams, J.C.,Wolanin, D.J.,Woolson, J.A. Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. J.Med.Chem., 37:3313-3326, 1994 Cited by PubMed: 7932559DOI: 10.1021/jm00046a016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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