1E1X

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027

1E1X の概要

• エントリーDOI: 10.2210/pdb1e1x/pdb
• 関連するPDBエントリー: 1AQ1 1B38 1B39 1BUH 1CKP 1E1V 1FIN 1HCK 1HCL 1JST 1JSU
• 分子名称: CYCLIN-DEPENDENT PROTEIN KINASE 2, 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34253.81

構造登録者

Endicott, J.A.,Noble, M.E.M.,Johnson, L.N. (登録日: 2000-05-11, 公開日: 2001-05-10, 最終更新日: 2023-12-06)

• 主引用文献: Arris, C.E.,Boyle, F.T.,Calvert, A.H.,Curtin, N.J.,Endicott, J.A.,Garman, E.F.,Gibson, A.E.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Lawrie, A.M.,Newell, D.R.,Noble, M.E.M.,Sausville, E.A.,Schultz, R.,Yu, W.; Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.; J.Med.Chem., 43:2797-, 2000; PubMed: 10956187; DOI: 10.1021/JM990628O

実験手法

X-RAY DIFFRACTION (1.85 Å)