Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1DM2

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

Summary for 1DM2
Entry DOI10.2210/pdb1dm2/pdb
DescriptorCYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains1
Total formula weight34548.89
Authors
Thunnissen, A.M.,Kim, S.-H. (deposition date: 1999-12-13, release date: 2000-05-31, Last modification date: 2024-02-07)
Primary citationMeijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R.
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7:51-63, 2000
Cited by
PubMed: 10662688
DOI: 10.1016/S1074-5521(00)00063-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon