1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

Summary for 1CJ1

Entry DOI	10.2210/pdb1cj1/pdb
Descriptor	PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER (3 entities in total)
Functional Keywords	signal transduction, sh2 domain, phosphotyrosine, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P62993
Total number of polymer chains	12
Total formula weight	142155.80
Authors	Rahuel, J. (deposition date: 1999-04-21, release date: 1999-12-22, Last modification date: 2023-08-02)
Primary citation	Furet, P.,Garcia-Echeverria, C.,Gay, B.,Schoepfer, J.,Zeller, M.,Rahuel, J. Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J.Med.Chem., 42:2358-2363, 1999 Cited by PubMed: 10395476 DOI: 10.1021/jm991013u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation