1BR8

IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN

Summary for 1BR8

Entry DOI	10.2210/pdb1br8/pdb
Descriptor	PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE) (3 entities in total)
Functional Keywords	serpins, antithrombin, binary-complex, heparin, polymerisation, thrombosis, emphysema, cirrhosis, blood clotting
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P01008
Total number of polymer chains	3
Total formula weight	99291.23
Authors	Skinner, R.,Chang, W.S.W.,Jin, L.,Pei, X.Y.,Huntington, J.A.,Abrahams, J.P.,Carrell, R.W.,Lomas, D.A. (deposition date: 1998-08-26, release date: 1998-09-02, Last modification date: 2023-08-09)
Primary citation	Skinner, R.,Chang, W.S.,Jin, L.,Pei, X.,Huntington, J.A.,Abrahams, J.P.,Carrell, R.W.,Lomas, D.A. Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. J.Mol.Biol., 283:9-14, 1998 Cited by PubMed: 9761669 DOI: 10.1006/jmbi.1998.2083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation