1BIL

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

1BIL の概要

• エントリーDOI: 10.2210/pdb1bil/pdb
• 分子名称: Renin, (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-[(1S,2R,3R)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-N~4~-[2-(d imethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide (3 entities in total)
• 機能のキーワード: aspartic proteinase, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75166.95

構造登録者

Tong, L. (登録日: 1995-09-27, 公開日: 1996-01-29, 最終更新日: 2022-03-09)

• 主引用文献: Tong, L.,Pav, S.,Lamarre, D.,Simoneau, B.,Lavallee, P.,Jung, G.; Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.; J.Biol.Chem., 270:29520-29524, 1995; PubMed: 7493993; DOI: 10.1074/jbc.270.49.29520

実験手法

X-RAY DIFFRACTION (2.4 Å)