1AQ1

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

Summary for 1AQ1

Entry DOI	10.2210/pdb1aq1/pdb
Descriptor	CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, staurosporine, cell division, mitosis, inhibition
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34443.02
Authors	Endicott, J.A.,Noble, M.E.M.,Johnson, L.N.,Lawrie, A.,Tunnah, P.,Brown, N.R. (deposition date: 1997-08-05, release date: 1997-11-12, Last modification date: 2023-08-02)
Primary citation	Lawrie, A.M.,Noble, M.E.,Tunnah, P.,Brown, N.R.,Johnson, L.N.,Endicott, J.A. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nat.Struct.Biol., 4:796-801, 1997 Cited by PubMed: 9334743 DOI: 10.1038/nsb1097-796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation