1AH3

ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR

Summary for 1AH3

Entry DOI	10.2210/pdb1ah3/pdb
Descriptor	ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total)
Functional Keywords	oxidoreductase, aldose reductase, inhibition, diabetes
Biological source	Sus scrofa (pig)
Cellular location	Cytoplasm: P80276
Total number of polymer chains	1
Total formula weight	36924.79
Authors	Moras, D.,Podjarny, A. (deposition date: 1997-04-12, release date: 1998-04-15, Last modification date: 2024-04-03)
Primary citation	Urzhumtsev, A.,Tete-Favier, F.,Mitschler, A.,Barbanton, J.,Barth, P.,Urzhumtseva, L.,Biellmann, J.F.,Podjarny, A.,Moras, D. A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil. Structure, 5:601-612, 1997 Cited by PubMed: 9195881 DOI: 10.1016/S0969-2126(97)00216-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation