8URO

Crystal structure of IgG1-Fc fragment (E382S) in complex with Corynebacterial ENGase CU43 (D187A-E189A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Corynebacterial protease CP40	polymer	415	46107.3	2	UniProt (A0A830QWM5)	Corynebacterium ulcerans
2	B, C, E, F (B, C, E, F)	Immunoglobulin gamma-1 heavy chain	polymer	232	26084.6	4	UniProt (P0DOX5)	Homo sapiens (human)

Sequence modifications

A, D: 32 - 412 (UniProt: A0A830QWM5)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Ser 8	-	expression tag
Ser 9	-	expression tag
Gly 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Pro 13	-	expression tag
Arg 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
Met 18	-	expression tag
Ala 19	-	expression tag
Ser 20	-	expression tag
Met 21	-	expression tag
Thr 22	-	expression tag
Gly 23	-	expression tag
Gly 24	-	expression tag
Gln 25	-	expression tag
Gln 26	-	expression tag
Met 27	-	expression tag
Gly 28	-	expression tag
Arg 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
Ala 187	Asp 187	engineered mutation
Ala 189	Glu 189	engineered mutation

B, C, E, F: 216 - 447 (UniProt: P0DOX5)

PDB	External Database	Details
Ser 382	Glu 384	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	196552.8
All*	Total formula weight	196552.8

*Water molecules are not included.