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7E35

Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43

Replaces:  7D7T
Summary for 7E35
Entry DOI10.2210/pdb7e35/pdb
Related7D6H
DescriptorNon-structural protein 3, ZINC ION, N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide (3 entities in total)
Functional Keywordsprotease, deubiquitinase, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains2
Total formula weight72300.80
Authors
Liu, J.,Wang, Y.,Xu, X.,Pan, L. (deposition date: 2021-02-08, release date: 2021-03-17, Last modification date: 2023-11-29)
Primary citationShan, H.,Liu, J.,Shen, J.,Dai, J.,Xu, G.,Lu, K.,Han, C.,Wang, Y.,Xu, X.,Tong, Y.,Xiang, H.,Ai, Z.,Zhuang, G.,Hu, J.,Zhang, Z.,Li, Y.,Pan, L.,Tan, L.
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2.
Cell Chem Biol, 28:855-, 2021
Cited by
PubMed: 33979649
DOI: 10.1016/j.chembiol.2021.04.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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