6OS9
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Neurotensin receptor type 1 | polymer | 435 | 48396.7 | 1 | UniProt (P30989) Pfam (PF00001) In PDB | Homo sapiens (Human) | NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH |
2 | L | JMV449 | polymer | 6 | 763.0 | 1 | synthetic construct | ||
3 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
5 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
6 | D | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus (mouse) |
Sequence modifications
R: 20 - 418 (UniProt: P30989)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp -19 | - | expression tag |
Tyr -18 | - | expression tag |
Lys -17 | - | expression tag |
Asp -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Ala -12 | - | expression tag |
Met -11 | - | expression tag |
Gly -10 | - | expression tag |
Gln -9 | - | expression tag |
Pro -8 | - | expression tag |
Gly -7 | - | expression tag |
Asn -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Ala -3 | - | expression tag |
Phe -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Ala 1 | - | expression tag |
Pro 2 | - | expression tag |
Asn 3 | - | expression tag |
Arg 4 | - | expression tag |
Ser 5 | - | expression tag |
His 6 | - | expression tag |
Ala 7 | - | expression tag |
Pro 8 | - | expression tag |
Asp 9 | - | expression tag |
His 10 | - | expression tag |
Asp 11 | - | expression tag |
Val 12 | - | expression tag |
Glu 13 | - | expression tag |
Asn 14 | - | expression tag |
Leu 15 | - | expression tag |
Tyr 16 | - | expression tag |
Phe 17 | - | expression tag |
Gln 18 | - | expression tag |
Gly 19 | - | expression tag |
Leu 85 | Ala 85 | engineered mutation |
- | Glu 282 | deletion |
- | His 283 | deletion |
- | Ser 284 | deletion |
- | Thr 285 | deletion |
- | Phe 286 | deletion |
- | Ser 287 | deletion |
- | Met 288 | deletion |
- | Ala 289 | deletion |
- | Ile 290 | deletion |
- | Glu 291 | deletion |
Leu 419 | - | expression tag |
Glu 420 | - | expression tag |
Val 421 | - | expression tag |
Leu 422 | - | expression tag |
Phe 423 | - | expression tag |
Gln 424 | - | expression tag |
Gly 425 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 162891.9 | |
All* | Total formula weight | 162891.9 |