6O0O

crystal structure of BCL-2 G101V mutation with S55746

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2	polymer	166	19399.6	2	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	A, C	~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide	non-polymer		710.8	2	Chemie (F3Q)
3		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A, C: 1 - 34 (UniProt: P10415)
A, C: 35 - 50 (UniProt: Q07817)
A, C: 51 - 166 (UniProt: P10415)

PDB	External Database	Details
Val 60	Gly 101	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38799.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1421.6
All*	Total formula weight	40220.9

*Water molecules are not included.