6NJI
Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 370 | 42593.1 | 2 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43,DPDE3,PDE43 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | 2-(4-{[4-(3-chlorophenyl)-6-ethyl-1,3,5-triazin-2-yl]amino}phenyl)ethan-1-ol | non-polymer | 354.8 | 2 | Chemie (KR4) | |||
| 5 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 244 - 582 (UniProt: Q08499)
A, B: 593 - 606 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 243 | - | expression tag |
| Ala 579 | Ser 654 | engineered mutation |
| Ala 581 | Ser 656 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 583 | - | linker |
| Leu 584 | - | linker |
| Asp 585 | - | linker |
| Glu 586 | - | linker |
| Gln 587 | - | linker |
| Asn 588 | - | linker |
| Arg 589 | - | linker |
| Asp 590 | - | linker |
| Ser 591 | - | linker |
| Gln 592 | - | linker |
| Glu 607 | - | expression tag |
| Asn 608 | - | expression tag |
| Leu 609 | - | expression tag |
| Tyr 610 | - | expression tag |
| Phe 611 | - | expression tag |
| Gln 612 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85186.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 889.1 | |
| All* | Total formula weight | 86075.2 |
