6N48
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera | polymer | 469 | 53471.0 | 1 | UniProt (A0A097J809) UniProt (P07550) Pfam (PF00001) In PDB | Enterobacteria phage RB59 | Lysis protein, Lysozyme, Muramidase,Beta-2 adrenoreceptor, Beta-2 adrenoceptor |
2 | B | Camelid Antibody Fragment | polymer | 120 | 12949.4 | 1 | Camelidae | Nanobody 6B9 | |
3 | A | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 1 | Chemie (P0G) | |||
4 | A | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate | non-polymer | 300.4 | 1 | Chemie (1WV) | |||
5 | A | N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine | non-polymer | 669.9 | 1 | Chemie (KBY) |
Sequence modifications
A: 867 - 1026 (UniProt: A0A097J809)
A: 1029 - 1262 (UniProt: P07550)
A: 1263 - 1348 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp 852 | - | expression tag |
Tyr 853 | - | expression tag |
Lys 854 | - | expression tag |
Asp 855 | - | expression tag |
Asp 856 | - | expression tag |
Asp 857 | - | expression tag |
Asp 858 | - | expression tag |
Ala 859 | - | expression tag |
Glu 860 | - | expression tag |
Asn 861 | - | expression tag |
Leu 862 | - | expression tag |
Tyr 863 | - | expression tag |
Phe 864 | - | expression tag |
Gln 865 | - | expression tag |
Gly 866 | - | expression tag |
Thr 919 | Cys 54 | engineered mutation |
Ala 962 | Cys 97 | engineered mutation |
Ala 1027 | - | linker |
Ala 1028 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 1096 | Met 96 | engineered mutation |
Thr 1098 | Met 98 | engineered mutation |
Glu 1187 | Asn 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 1265 | Cys 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66420.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1340.7 | |
All* | Total formula weight | 67761.1 |