6J5L
Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10e
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | High affinity nerve growth factor receptor | polymer | 303 | 34261.6 | 1 | UniProt (P04629) Pfam (PF07714) In PDB | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | A | N-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide | non-polymer | 477.6 | 1 | Chemie (B9C) | |||
| 3 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A: 502 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly 494 | - | expression tag |
| Ala 495 | - | expression tag |
| Met 496 | - | expression tag |
| Gly 497 | - | expression tag |
| Ser 498 | - | expression tag |
| Gly 499 | - | expression tag |
| Ile 500 | - | expression tag |
| Arg 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34261.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 477.6 | |
| All* | Total formula weight | 34739.2 |
