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6HRP

CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4-dihydroisoquinolin-1-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ATyrosine-protein kinase BTKpolymer28332521.11UniProt (Q06187)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase
2A6-~{tert}-butyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[(5-morpholin-4-ylcarbonylpyridin-2-yl)amino]-6-oxidanylidene-pyridazin-3-yl]phenyl]phthalazin-1-onenon-polymer639.71Chemie (GMQ)
3waterwater18.0444Chemie (HOH)
Sequence modifications
A: 378 - 659 (UniProt: Q06187)
PDBExternal DatabaseDetails
Gly 377-expression tag
Ala 489Met 523engineered mutation
Ala 492Arg 526engineered mutation
Ala 624Glu 658engineered mutation
Ala 625Lys 659engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight32521.1
Non-Polymers*Number of molecules1
Total formula weight639.7
All*Total formula weight33160.8
*Water molecules are not included.

217705

數據於2024-03-27公開中

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