Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6GGD

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BCellular tumor antigen p53polymer21924530.82UniProt (P04637)
Pfam (PF00870)
In PDB
Homo sapiens (Human)Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, B[9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azaniumnon-polymer306.42Chemie (EYB)
4BGLYCEROLnon-polymer92.11Chemie (GOL)
5waterwater18.0364Chemie (HOH)
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
PDBExternal DatabaseDetails
Leu 133Met 133engineered mutation
Ala 203Val 203engineered mutation
Cys 220Tyr 220engineered mutation
Tyr 239Asn 239engineered mutation
Asp 268Asn 268engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight49061.6
Non-Polymers*Number of molecules5
Total formula weight835.7
All*Total formula weight49897.3
*Water molecules are not included.

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon